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Article

Estimation of bias in nongenetic observational studies using "mendelian triangulation".

Annals of epidemiology - 1 Sept 2006

Bautista Leonelo E, Smeeth Liam, Hingorani Aroon D, Casas Juan P

Abstract excerpt

PURPOSE: Phenotype-disease odds ratios calculated from the effect of a genotype on its phenotype and on disease risk ("Mendelian triangulation") can be used as a standard to assess bias on the corresponding odds ratio from nongenetic studies. Statistical tests are commonly used to compare these odds ratios. We propose a method to estimate the magnitude of the bias and judge the validity of the phenotype-disease...

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Identifiers

PMID: 16621596
DOI: 10.1016/j.annepidem.2006.02.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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