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Article

Single-variant and multi-variant trend tests for genetic association with next-generation sequencing that are robust to sequencing error.

Human heredity - 1 Jan 2012

Kim Wonkuk, Londono Douglas, Zhou Lisheng, Xing Jinchuan, Nato Alejandro Q, Musolf Anthony, Matise Tara C, Finch Stephen J, Gordon Derek

Abstract excerpt

As with any new technology, next-generation sequencing (NGS) has potential advantages and potential challenges. One advantage is the identification of multiple causal variants for disease that might otherwise be missed by SNP-chip technology. One potential challenge is misclassification error (as with any emerging technology) and the issue of power loss due to multiple testing. Here, we develop an extension of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23594495
DOI: 10.1159/000346824
PMCID: PMC3863939

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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