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Article

Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer

17 Jul 2008

Abstract excerpt

BACKGROUND AND AIMS: Chromosomal instability (CIN) is recognised as a hallmark of cancer and is caused by a spindle assembly checkpoint disorder or chromosome mis-segregation during mitosis. Although the recent identification of human shugoshin (hSgo1), an important player in proper chromosome segregation, has suggested the involvement of hSgo1 in colorectal tumourigenesis, little is known about how it is...

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Share to Genetic factors in colorectal cancer
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Share to Microtubule and mitosis dynamics

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PMID: 18635744
DOI: 10.1136/gut.2008.149468

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