Article
Absence of BRAF gene mutation in non-melanoma skin tumors.
Cell cycle (Georgetown, Tex.) - 1 May 2006
Libra Massimo, Malaponte Grazia, Bevelacqua Valentina, Siciliano Roberta, Castrogiovanni Paola, Fulvi Alberto, Micali Giuseppe, Ligresti Giovanni, Mazzarino Maria C, Stivala Franca, Travali Salvatore, McCubrey James A
Abstract excerpt
Basal cell carcinoma (BCC) is the most common skin cancer, and its incidence is increasing. It was proposed that the RAS oncogene significantly contributes to skin cancer development. Numerous BRAF mutations have been detected in melanoma biopsy specimens and cell lines. For the first time, in the present study, tumor biopsy specimens from 78 patients with BCC were screened for BRAF mutation within exons 11 and...
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