Article
BRAF as a melanoma susceptibility candidate gene?
Cancer research - 15 Jun 2003
Laud Karine, Kannengiesser Caroline, Avril Marie-Francoise, Chompret Agnès, Stoppa-Lyonnet Dominique, Desjardins Laurence, Eychene Alain, Demenais Florence, Lenoir Gilbert M, Bressac-de Paillerets Brigitte
Abstract excerpt
A high frequency of activating BRAF somatic mutations have been identified recently in malignant melanoma and nevi indicating that BRAF activation could be an early and critical step in the initiation of melanocytic neoplasia. To determine whether BRAF mutations could be an earlier event occurring at the germline level, we screened the entire BRAF coding region for germline mutations in 80 independent...
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