Article
BRAF and RKIP are significantly decreased in cutaneous squamous cell carcinoma.
Cell cycle (Georgetown, Tex.) - 1 May 2009
Zaravinos Apostolos, Kanellou Peggy, Baritaki Stavroula, Bonavida Benjamin, Spandidos Demetrios A
Abstract excerpt
BACKGROUND: Actinic keratosis (AK) is a well-established pre-cancerous skin lesion that has the potential to progress to squamous cell carcinoma (SCC). However, little is known about the implication of BRAF and RKIP expression, or about the incidence of BRAF mutations in the formation of these cutaneous diseases. The RAS oncogene has been proposed to significantly contribute to skin cancer development. Moreover,...
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