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Article

Detection of BRAF gene mutation in primary choroidal melanoma tissue.

Cancer biology & therapy - 1 Feb 2006

Malaponte Grazia, Libra Massimo, Gangemi Pietro, Bevelacqua Valentina, Mangano Katia, D'Amico Fabio, Mazzarino Maria C, Stivala Franca, McCubrey James A, Travali Salvatore

Abstract excerpt

Numerous BRAF mutations have been detected in melanoma biopsy specimens and cell lines. In contrast, several studies report lack of BRAF mutations in uveal melanoma including primary and metastatic choroidal and ciliary body melanomas. To our knowledge, for the first time, here we report a case of choroidal melanoma harboring the BRAF mutation (V600E). The activation of RAF/MEK/ERK pathway, although independent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16410717
DOI: 10.4161/cbt.5.2.2429

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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