Article
Increased expression of the glucocorticoid receptor-A translational isoform as a result of the ER22/23EK polymorphism.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 2005
Russcher Henk, van Rossum Elisabeth F C, de Jong Frank H, Brinkmann Albert O, Lamberts Steven W J, Koper Jan W
Abstract excerpt
One of the most intriguing polymorphisms in the GR [glucocorticoid (GC) receptor] gene is in codons 22 and 23 [GAGAGG(GluArg) --> GAAAAG (GluLys)]. This polymorphism is associated with a reduced GC sensitivity, a better metabolic and cardiovascular health profile, and an increased survival rate. Recently, Yudt and Cidlowski reported that two different methionine codons in the GR mRNA may be used as initiation...
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