Article
Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice.
Mechanisms of development - 1 May 2006
Schild Andreas, Isenmann Stefan, Tanimoto Naoyuki, Tonagel Felix, Seeliger Mathias W, Ittner Lars M, Kretz Alexandra, Ogris Egon, Götz Jürgen
Abstract excerpt
Although Harderian glands are especially large in rodents, many features of this retroocular gland, including its development and function, are not well established. Protein phosphatase 2A (PP2A) is a family of heterotrimeric enzymes expressed in this gland. PP2A substrate specificity is determined by regulatory subunits with leucine 309 of the catalytic subunit playing a crucial role in the recruitment of...
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