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Article

SKAP1 protein PH domain determines RapL membrane localization and Rap1 protein complex formation for T cell receptor (TCR) activation of LFA-1.

The Journal of biological chemistry - 26 Aug 2011

Raab Monika, Smith Xin, Matthess Yves, Strebhardt Klaus, Rudd Christopher E

Abstract excerpt

Although essential for T cell function, the identity of the T cell receptor (TCR) "inside-out" pathway for the activation of lymphocyte function-associated antigen 1 (LFA-1) is unclear. SKAP1 (SKAP-55) is the upstream regulator needed for TCR-induced RapL-Rap1 complex formation and LFA-1 activation. In this paper, we show that SKAP1 is needed for RapL binding to membranes in a manner dependent on the PH domain of...

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PMID: 21669874
DOI: 10.1074/jbc.M111.222661
PMCID: PMC3191007

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SKAP1

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SKAP1 protein PH domain determines RapL membrane localization and Rap1 protein complex formation for T cell receptor (TCR) activation of LFA-1.PMID 21669874Read ↗

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