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Article

The structure of the yFACT Pob3-M domain, its interaction with the DNA replication factor RPA, and a potential role in nucleosome deposition.

Molecular cell - 5 May 2006

VanDemark Andrew P, Blanksma Mary, Ferris Elliott, Heroux Annie, Hill Christopher P, Formosa Tim

Abstract excerpt

We report the crystal structure of the middle domain of the Pob3 subunit (Pob3-M) of S. cerevisiae FACT (yFACT, facilitates chromatin transcription), which unexpectedly adopts an unusual double pleckstrin homology (PH) architecture. A mutation within a conserved surface cluster in this domain causes a defect in DNA replication that is suppressed by mutation of replication protein A (RPA). The nucleosome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16678108
DOI: 10.1016/j.molcel.2006.03.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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