Predisposition of antituberculosis drug induced hepatotoxicity by cytochrome P450 2E1 genotype and haplotype in pediatric patients

Abstract excerpt

To the Editor, Previous reports have shown that polymorphisms in NAT2 and CYP450 2E1 genes contribute to antituberculosis drug (ATD)-induced hepatotoxicity in adults in different populations.1–3 In the present study, the association between risk of hepatotoxicity and polymorphisms in these genes was examined in children. The study involved 111 pediatric patients with tuberculosis (TB). Most of the patients were...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Drug-Induced Hepatotoxicity and Protection
• Share to Pharmacogenetics and Drug Metabolism
• Share to Tuberculosis Research and Epidemiology