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Article

Impact of glutathione S-transferase M1 and T1 on anti-tuberculosis drug-induced hepatotoxicity in Chinese pediatric patients.

PloS one - 1 Jan 2014

Liu Fang, Jiao An-xia, Wu Xi-rong, Zhao Wei, Yin Qing-qin, Qi Hui, Jiao Wei-wei, Xiao Jing, Sun Lin, Shen Chen, Tian Jian-ling, Shen Dan, Jacqz-Aigrain Evelyne, Shen A-dong

Abstract excerpt

BACKGROUND: Anti-tuberculosis drug induced hepatotoxicity (ATDH) is a major adverse drug reaction associated for anti-tuberculosis therapy. The glutathione S-transferases (GST) plays a crucial role in the detoxification of hepatotoxic metabolites of anti-tuberculosis drugs.An association between GSTM1/GSTT1 null mutations and increased risk of ATDH has been demonstrated in adults. Given the ethnic differences and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemical and Drug Induced Liver Injury

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Source

Open in PubMed Open full text

Identifiers

PMID: 25525805
DOI: 10.1371/journal.pone.0115410
PMCID: PMC4272297

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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