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Insulin-Like Growth Factor Binding Protein-5 in Physiology and Disease

3 Mar 2020

Abstract excerpt

Insulin-like growth factor (IGF) signaling is regulated by a conserved family of IGF binding proteins (IGFBPs) in vertebrates. Among the six distinct types of IGFBPs, IGFBP-5 is the most highly conserved across species and has the broadest range of biological activities. IGFBP-5 is expressed in diverse cell types, and its expression level is regulated by a variety of signaling pathways in different contexts....

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PMID: 32194505
DOI: 10.3389/fendo.2020.00100

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