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Article

Increased startle responses in mice carrying mutations of glycine receptor subunit genes.

Neuroreport - 29 Feb 1996

Koch M, Kling C, Becker C M

Abstract excerpt

An exaggerated startle response caused by mutations of the alpha 1 subunit gene of the inhibitory glycine receptor (GLRA1) is the key symptom of human hyperekplexia or startle disease. The recessive mouse mutant spasmodic (spd) carries a missense mutation in the corresponding murine Glra1 gene which reduces the affinity of agonists for the mutant receptor. This mutant has been regarded as an animal model with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8733750
DOI: 10.1097/00001756-199602290-00030

Genes

GLRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Increased startle responses in mice carrying mutations of glycine receptor subunit genes.PMID 8733750Read ↗

Increased sensitization of acoustic startle response in spasmodic mice with a mutation of the glycine receptor alpha1-subunit gene.Semantic proximity Read ↗

A missense mutation in the gene encoding the alpha 1 subunit of the inhibitory glycine receptor in the spasmodic mouse.Semantic proximity Read ↗

Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants spastic, spasmodic, and oscillator.Semantic proximity Read ↗

Glycine receptor mouse mutants: model systems for human hyperekplexia.Semantic proximity Read ↗

Functional recovery of glycine receptors in spastic murine model of startle disease.Semantic proximity Read ↗

Glycine receptor knock-in mice and hyperekplexia-like phenotypes: comparisons with the null mutant.Semantic proximity Read ↗

A GLRA1 null mutation in recessive hyperekplexia challenges the functional role of glycine receptors.Semantic proximity Read ↗

Transient neuromotor phenotype in transgenic spastic mice expressing low levels of glycine receptor beta-subunit: an animal model of startle disease.Semantic proximity Read ↗

The glycinergic system in human startle disease: a genetic screening approachSemantic proximity Read ↗

Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor (GLRB).Semantic proximity Read ↗

Distinct phenotypes in zebrafish models of human startle disease.Semantic proximity Read ↗

Disorders of the inhibitory glycine receptor: the spastic mouse.Semantic proximity Read ↗

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