Increased startle responses in mice carrying mutations of glycine receptor subunit genes.

doi:10.1097/00001756-199602290-00030

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Article

Increased startle responses in mice carrying mutations of glycine receptor subunit genes.

Neuroreport - 29 Feb 1996

Koch M, Kling C, Becker C M

Abstract excerpt

An exaggerated startle response caused by mutations of the alpha 1 subunit gene of the inhibitory glycine receptor (GLRA1) is the key symptom of human hyperekplexia or startle disease. The recessive mouse mutant spasmodic (spd) carries a missense mutation in the corresponding murine Glra1 gene wh...

Topics

Acoustic Stimulation
Animals
Female
Male
Mice
Mice, Inbred C57BL
Muscle Spasticity
Mutagenesis, Insertional
Mutation
Receptors, Glycine
Reflex, Startle

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