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Article

Phenotypic heterogeneity and disease course in three murine strains with mutations in genes encoding for alpha 1 and beta glycine receptor subunits.

Movement disorders : official journal of the Movement Disorder Society - 1 Mar 1997

Simon E S

Abstract excerpt

Impaired glycinergic inhibition causes human hyperekplexia, and may be involved in the pathogenesis of movement disorders associated with uremia, spinal cord lesions, DDT poisoning, and tetanus. Three autosomal recessive mutant mouse strains with single-gene mutations affecting either the alpha 1...

Topics

Animals
Chromosome Aberrations
Chromosome Disorders
DNA Mutational Analysis
Female
Genes, Recessive
Genetic Carrier Screening
Humans
Male
Mice
Mice, Neurologic Mutants
Motor Activity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Receptors, Glycine

Species Specificity

Spinal Cord

Source

Identifiers

PMID: 9087981
DOI: 10.1002/mds.870120213

Genes

DDT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9087981-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Phenotypic heterogeneity and disease course in three murine strains with mutations in genes encoding for alpha 1 and beta glycine receptor subunits.PMID 9087981Read ↗

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