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Article

Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBPalpha.

Blood - 15 Aug 2006

Ferrari-Amorotti Giovanna, Keeshan Karen, Zattoni Michela, Guerzoni Clara, Iotti Giorgio, Cattelani Sara, Donato Nick J, Calabretta Bruno

Abstract excerpt

Chronic phase-to-blast crisis transition in chronic myelogenous leukemia (CML) is associated with differentiation arrest and down-regulation of C/EBPalpha, a transcription factor essential for granulocyte differentiation. Patients with CML in blast crisis (CML-BC) became rapidly resistant to therapy with the breakpoint cluster region-Abelson murine leukemia (BCR/ABL) kinase inhibitor imatinib (STI571) because of...

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Identifiers

PMID: 16670262
DOI: 10.1182/blood-2006-01-011833
PMCID: PMC1895881

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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