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Article

Restoration of C/EBPalpha expression in a BCR-ABL+ cell line induces terminal granulocytic differentiation.

The Journal of biological chemistry - 26 Dec 2003

Tavor Sigal, Park Dorothy J, Gery Sigal, Vuong Peter T, Gombart Adrian F, Koeffler H Phillip

Abstract excerpt

The transcription factor C/EBPalpha plays a critical role in the process of granulocytic differentiation. Recently, mutations that abrogated transcriptional activation of C/EBPalpha were detected in acute myeloid leukemia patient samples. Moreover, the progression of chronic myelogenous leukemia (CML) to blast crisis in patients was correlated with down-modulation of C/EBPalpha. The KCL22 cell line, derived from...

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Share to CCAAT-Enhancer-Binding Protein-alpha
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fusion Proteins, bcr-abl

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Source

Identifiers

PMID: 14517214
DOI: 10.1074/jbc.M307077200

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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