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Article

Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras.

Proceedings of the National Academy of Sciences of the United States of America - 9 May 2006

Pietschmann Thomas, Kaul Artur, Koutsoudakis George, Shavinskaya Anna, Kallis Stephanie, Steinmann Eike, Abid Karim, Negro Francesco, Dreux Marlene, Cosset Francois-Loic, Bartenschlager Ralf

Abstract excerpt

Chronic liver disease caused by infection with hepatitis C virus (HCV) is an important global health problem that currently affects 170 million people. A major impediment in HCV research and drug development has been the lack of culture systems supporting virus production. This obstacle was recently overcome by using JFH1-based full-length genomes that allow production of viruses infectious both in vitro and in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16651538
DOI: 10.1073/pnas.0504877103
PMCID: PMC1455439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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