Article
A comprehensive structure-function comparison of hepatitis C virus strain JFH1 and J6 polymerases reveals a key residue stimulating replication in cell culture across genotypes.
Journal of virology - 1 Mar 2011
Schmitt Melanie, Scrima Nathalie, Radujkovic Danijela, Caillet-Saguy Célia, Simister Philip C, Friebe Peter, Wicht Oliver, Klein Rahel, Bartenschlager Ralf, Lohmann Volker, Bressanelli Stéphane
Abstract excerpt
The hepatitis C virus (HCV) genotype 2a isolate JFH1 represents the only cloned HCV wild-type sequence capable of efficient replication in cell culture as well as in vivo. Previous reports have pointed to NS5B, the viral RNA-dependent RNA polymerase (RdRp), as a major determinant for efficient replication of this isolate. To understand the contribution of the JFH1 NS5B gene at the molecular level, we aimed at...
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