Article
Full-length infectious HCV chimeras.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009
Pietschmann Thomas
Abstract excerpt
One hallmark of HCV is its pronounced genetic plasticity, caused by error-prone RNA replication, which probably contributes to its remarkable ability to establish chronic infections. On the basis of phylogenetic analyses, HCV variants are classified into six genotypes (GTs), each comprising a variable number of subtypes. Presumably, these genetic differences, which range from 33 to 35% at the nucleotide level...
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