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Article

Mapping Determinants of Hepatitis C Virus E1/E2 Transmembrane Interactions Using Intergenotypic Chimeras.

Viruses - 28 May 2026

Fanalista Margherita, Olesen Christina Holmboe, Velázquez-Moctezuma Rodrigo, Bukh Jens, Prentoe Jannick

Abstract excerpt

Hepatitis C virus (HCV) infection remains a major global health burden, and no vaccine preventing chronic infection is available. The envelope glycoproteins, E1 and E2, form a complex essential for viral entry; however, the mechanisms governing E1/E2 assembly and stability remain incompletely defined. Here, we investigated the role of the E1/E2 transmembrane (TM) regions in HCV infectivity using chimeras of...

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Identifiers

PMID: 42357626
DOI: 10.3390/v18060616
PMCID: PMC13308042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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