Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of hepatitis C virus intra- and intergenotypic chimeras reveals a role of the glycoproteins in virus envelopment.

Journal of virology - 1 Dec 2013

Steinmann Eike, Doerrbecker Juliane, Friesland Martina, Riebesehl Nina, Ginkel Corinne, Hillung Julia, Gentzsch Juliane, Lauber Chris, Brown Richard, Frentzen Anne, Pietschmann Thomas

Abstract excerpt

Hepatitis C virus (HCV) is highly variable and associated with chronic liver disease. Viral isolates are grouped into seven genotypes (GTs). Accumulating evidence indicates that viral determinants in the core to NS2 proteins modulate the efficiency of virus production. However, the role of the glycoproteins E1 and E2 in this process is currently poorly defined. Therefore, we constructed chimeric viral genomes to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Chimera

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Hepacivirus

Share to Hepatitis C

Share to Hepatitis C virus research

Share to Viral Envelope Proteins

Share to Virus Assembly

Source

Open in PubMed Open full text

Identifiers

PMID: 24089562
DOI: 10.1128/JVI.01708-13
PMCID: PMC3838269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of hepatitis C virus intra- and intergenotypic chimeras reveals a role of the glycoproteins in virus envelopment.PMID 24089562Read ↗

Mapping Determinants of Hepatitis C Virus E1/E2 Transmembrane Interactions Using Intergenotypic Chimeras.Semantic proximity Read ↗

Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras.Semantic proximity Read ↗

Cloning, expression, and functional analysis of patient-derived hepatitis C virus glycoproteins.Semantic proximity Read ↗

Compensatory mutations in E1, p7, NS2, and NS3 enhance yields of cell culture-infectious intergenotypic chimeric hepatitis C virus.Semantic proximity Read ↗

Functional Analysis of Hepatitis C Virus (HCV) Envelope Protein E1 Using a trans -Complementation System Reveals a Dual Role of a Putative Fusion Peptide of E1 in both HCV Entry and MorphogenesisSemantic proximity Read ↗

Hepatitis C virus nonstructural protein 5B is involved in virus morphogenesis.Semantic proximity Read ↗

Hepatitis C Virus Envelope Glycoprotein E1 Forms Trimers at the Surface of the Virion.Semantic proximity Read ↗

Analysis of hepatitis C virus core/NS5A protein co-localization using novel cell culture systems expressing core-NS2 and NS5A of genotypes 1-7.Semantic proximity Read ↗

A genetic interaction between the core and NS3 proteins of hepatitis C virus is essential for production of infectious virus.Semantic proximity Read ↗

Biogenesis of hepatitis C virus envelope glycoproteinsSemantic proximity Read ↗

Construction and characterization of chimeric hepatitis C virus E2 glycoproteins: analysis of regions critical for glycoprotein aggregation and CD81 binding.Semantic proximity Read ↗

Characterization of fusion determinants points to the involvement of three discrete regions of both E1 and E2 glycoproteins in the membrane fusion process of hepatitis C virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.