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Article

Groucho/transducin-like Enhancer-of-split (TLE)-dependent and -independent transcriptional regulation by Runx3.

Proceedings of the National Academy of Sciences of the United States of America - 9 May 2006

Yarmus Merav, Woolf Eilon, Bernstein Yael, Fainaru Ofer, Negreanu Varda, Levanon Ditsa, Groner Yoram

Abstract excerpt

Regulation of gene expression by tissue-specific transcription factors involves both turning on and turning off transcription of target genes. Runx3, a runt-domain transcription factor, regulates cell-intrinsic functions by activating and repressing gene expression in sensory neurons, dendritic cells (DC), and T cells. To investigate the mechanism of Runx3-mediated repression in an in vivo context, we generated...

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Identifiers

PMID: 16651517
DOI: 10.1073/pnas.0602470103
PMCID: PMC1464349

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