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Article

Mechanisms of compartmentalized expression of Mrg class G-protein-coupled sensory receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Jan 2008

Liu Yang, Yang Fu-Chia, Okuda Tsukasa, Dong Xinzhong, Zylka Mark J, Chen Chih-Li, Anderson David J, Kuner Rohini, Ma Qiufu

Abstract excerpt

Mrg class G-protein-coupled receptors (GPCRs) are expressed exclusively in sensory neurons in the trigeminal and dorsal root ganglia. Pharmacological activation of Mrg proteins is capable of modulating sensory neuron activities and elicits nociceptive effects. In this study, we illustrate a control mechanism that allows the Runx1 runt domain transcription factor to generate compartmentalized expression of these...

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Identifiers

PMID: 18171930
DOI: 10.1523/JNEUROSCI.4472-07.2008
PMCID: PMC6671167

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