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Article

TLE, the Human Homolog of Groucho, Interacts with AML1 and Acts as a Repressor of AML1-Induced Transactivation

1 Nov 1998

Abstract excerpt

The AML1 gene encodes DNA-binding proteins that contain the Runt domain and is found at the breakpoints of some translocations associated with leukemias. It has been reported that AML1 plays pivotal roles in myeloid differentiation, probably through the transcriptional regulation of various hematopoietic genes. Here we demonstrate the physical and the functional interaction between AML1 and TLE1 (transducin-like...

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Identifiers

PMID: 9837750
DOI: 10.1006/bbrc.1998.9705

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

TLE, the Human Homolog of Groucho, Interacts with AML1 and Acts as a Repressor of AML1-Induced TransactivationPMID 9837750Read ↗

Mammalian runt‐domain proteins and their roles in hematopoiesis, osteogenesis, and leukemiaSemantic proximity Read ↗

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MEIS2 Is an Oncogenic Partner in AML1-ETO-Positive AMLSemantic proximity Read ↗

Inhibition of the Transforming Growth Factor β1 Signaling Pathway by the AML1/ETO Leukemia-associated Fusion ProteinSemantic proximity Read ↗

Aristaless-related homeobox gene, the gene responsible for West syndrome and related disorders, is a Groucho/transducin-like enhancer of split dependent transcriptional repressor.Semantic proximity Read ↗

Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression.Semantic proximity Read ↗

AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES proteinSemantic proximity Read ↗

Conservation and function of the transcriptional regulatory protein Runt.Semantic proximity Read ↗

The nuclear receptor co-repressor (N-CoR) utilizes repression domains I and III for interaction and co-repression with ETO.Semantic proximity Read ↗

The hematopoietic regulator TAL1 is required for chromatin looping between the β-globin LCR and human γ-globin genes to activate transcriptionSemantic proximity Read ↗

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