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Article

Groucho co-repressor proteins regulate β cell development and proliferation by repressing Foxa1 in the developing mouse pancreas.

Development (Cambridge, England) - 24 Mar 2021

Theis Alexandra, Singer Ruth A, Garofalo Diana, Paul Alexander, Narayana Anila, Sussel Lori

Abstract excerpt

Groucho-related genes (GRGs) are transcriptional co-repressors that are crucial for many developmental processes. Several essential pancreatic transcription factors are capable of interacting with GRGs; however, the in vivo role of GRG-mediated transcriptional repression in pancreas development is still not well understood. In this study, we used complex mouse genetics and transcriptomic analyses to determine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33658226
DOI: 10.1242/dev.192401
PMCID: PMC8015241

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