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Article

Angiotensin type-1 receptor A1166C gene polymorphism correlates with oxidative stress levels in human heart failure.

Hypertension (Dallas, Tex. : 1979) - 1 Jun 2006

Cameron Vicky A, Mocatta Tessa J, Pilbrow Anna P, Frampton Chris M, Troughton Richard W, Richards A Mark, Winterbourn Christine C

Abstract excerpt

Oxidative stress plays a critical role in the pathogenesis of cardiovascular disease and diabetes. Studies in vascular cells and experimental animals have demonstrated that the angiotensin type-1 receptor (AT1R) contributes to formation of reactive oxygen species by activating nicotinamide-adenine dinucleotide phosphate oxidases, but the relevance of this pathway to human heart disease has not been established....

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PMID: 16651460
DOI: 10.1161/01.HYP.0000222893.85662.cd

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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