Article
Alpha2-macroglobulin, lipoprotein receptor-related protein and lipoprotein receptor-associated protein and the genetic risk for developing Alzheimer's disease.
Neuroscience letters - 12 Jun 2006
Depboylu Candan, Lohmüller Frank, Du Yansheng, Riemenschneider Matthias, Kurz Alexander, Gasser Thomas, Müller Ulrich, Dodel Richard C
Abstract excerpt
Alpha2-macroglobulin (alpha2M) as well as its receptor, the low-density lipoprotein receptor-related (LRP) and the receptor-associated protein (RAP) are involved in the clearance of cerebral A beta. Current evidence suggests that polymorphisms in the genes of alpha2M, LRP and RAP may have functional effects on the proteins. Two independent association samples of 271 AD patients and 280 representative controls...
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