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Article

Relating HIV-1 Sequence Variation to Replication Capacity via Trees and Forests

12 Jan 2004

Abstract excerpt

The problem of relating genotype (as represented by amino acid sequence) to phenotypes is distinguished from standard regression problems by the nature of sequence data. Here we investigate an instance of such a problem where the phenotype of interest is HIV-1 replication capacity and contiguous segments of protease and reverse transcriptase sequence constitutes genotype. A variety of data analytic methods have...

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PMID: 16646798
DOI: 10.2202/1544-6115.1031

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