Article
An update to the HIV-TRePS system: the development of new computational models that do not require a genotype to predict HIV treatment outcomes.
The Journal of antimicrobial chemotherapy - 1 Apr 2014
Revell Andrew D, Wang Dechao, Wood Robin, Morrow Carl, Tempelman Hugo, Hamers Raph, Alvarez-Uria Gerardo, Streinu-Cercel Adrian, Ene Luminita, Wensing Annemarie, Reiss Peter, van Sighem Ard I, Nelson Mark, Emery Sean, Montaner Julio S G, Lane H Clifford, Larder Brendan A
Abstract excerpt
OBJECTIVES: The optimal individualized selection of antiretroviral drugs in resource-limited settings is challenging because of the limited availability of drugs and genotyping. Here we describe the development of the latest computational models to predict the response to combination antiretroviral therapy without a genotype, for potential use in such settings. METHODS: Random forest models were trained to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.