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Article

Intramolecular controls for the generation of clinical-quality SNP genotypes and the assessment of normal heterozygote imbalance.

Electrophoresis - 1 May 2006

McKeown Brian, Rowan Paul, Sung Robert, Derbyshire Roger

Abstract excerpt

We present an inventive method that generates intramolecular controls for SNP analysis, termed Mirror SNPs. Using the ovine diseases of callipyge and scrapie as examples, we describe the PCR-driven production of balanced heterozygote copies of the various SNPs implicated in these diseases. In the absence of a callipyge-positive control DNA, we generated a balanced heterozygote Mirror SNP that represents both the...

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PMID: 16645948
DOI: 10.1002/elps.200500015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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