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Article

Analysis of multiple single nucleotide polymorphisms closely positioned in the ovine PRNP gene using linear fluorescent probes and melting curve analysis.

BMC infectious diseases - 3 Aug 2007

French David J, Jones Dominic, McDowell David G, Thomson Jim A, Debenham Paul G

Abstract excerpt

BACKGROUND: Resistance and susceptibility to scrapie has been associated with single nucleotide polymorphisms located within codons 136, 154 and 171 of the ovine prion protein gene (PRNP). Dual-labelled HyBeacon probes were developed to analyse single and clustered polymorphisms within these and neighbouring codons. METHODS: Extracted DNAs and unpurified blood samples were genotyped with respect to polymorphisms...

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Identifiers

PMID: 17683552
DOI: 10.1186/1471-2334-7-90
PMCID: PMC1994165

Genes

PRNP

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Analysis of multiple single nucleotide polymorphisms closely positioned in the ovine PRNP gene using linear fluorescent probes and melting curve analysis.PMID 17683552Read ↗

Genotyping of ovine prion protein gene (PRNP) variants by PCR with melting curve analysis.Semantic proximity Read ↗

A dual fluorescent multiprobe assay for prion protein genotyping in sheep.Semantic proximity Read ↗

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Development of an assay to determine single nucleotide polymorphisms in the prion gene for the genetic diagnosis of relative susceptibility to classical scrapie in sheep.Semantic proximity Read ↗

Technical note: determination of alleles of the ovine PRNP gene using PCR-single-strand conformational polymorphism analysis.Semantic proximity Read ↗

Adaptation of a low-cost medium-throughput genotyping system for ovine prion protein gene polymorphims associated with scrapie.Semantic proximity Read ↗

A new genotyping strategy for efficient scoring of closely positioned SNPs in the ovine prion protein gene.Semantic proximity Read ↗

Novel quantitative real-time LCR for the sensitive detection of SNP frequencies in pooled DNA: method development, evaluation and application.Semantic proximity Read ↗

A decade of using small-to-medium throughput allele discrimination assay to determine prion protein gene ( Prnp) genotypes in sheep in Slovenia.Semantic proximity Read ↗

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