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Article

Genetic and epigenetic analysis of the TIMP-3 gene in ovarian cancer.

Cancer letters - 8 Mar 2007

Liu Mira C P, Choong David Y H, Hooi Christine S F, Williams Louise H, Campbell Ian G

Abstract excerpt

Chromosome 22q shows a high frequency of loss of heterozygosity (LOH) in ovarian cancers suggesting the existence of one or more important tumor suppressor genes (TSGs). The tissue inhibitor of metalloproteinase-3 (TIMP-3) is a plausible TSG candidate since it is often encompassed within these regions of LOH. TIMP-3 has not previously been investigated for somatic mutations or promoter hypermethylation in ovarian...

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Share to Chromosomes, Human, Pair 22
Share to DNA Methylation
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

Share to Ovarian Neoplasms

Share to Polymorphism, Single-Stranded Conformational

Share to Promoter Regions, Genetic

Share to Tissue Inhibitor of Metalloproteinases

Source

Identifiers

PMID: 16644110
DOI: 10.1016/j.canlet.2006.03.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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