Article
Analysis of two polymorphisms in the promoter region of matrix metalloproteinase 1 and 3 genes in women with endometriosis.
Acta obstetricia et gynecologica Scandinavica - 1 Jan 2006
Ferrari Maria Maddalena, Biondi Maria Luisa, Rossi Gabriela, Grijuela Barbara, Gaita Sara, Perugino Giuseppe, Viganò Paola
Abstract excerpt
BACKGROUND: Matrix metalloproteinases are a family of proteolytic enzymes that can degrade extracellular matrix components and have been implicated in connective tissue remodeling associated with cancer invasion and metastasis. These proteins are also involved in the invasive events underlying endometriotic lesion formation and aggressive behavior. Given the established genetic background of endometriosis, the...
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