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Frequent Methylation-Associated Silencing of the<i>Tissue Inhibitor of Metalloproteinase-3</i>Gene in Pancreatic Endocrine Tumors

1 Mar 2003

Abstract excerpt

Molecular mechanisms contributing to the tumorigenesis of pancreatic endocrine tumors (PETs) are still not well understood. Allelic deletions at chromosome 22q12.3 were detected in about 30-60% of PETs, suggesting that inactivation of one or more tumor suppressor genes on this chromosomal arm is important for their pathogenesis. Because the putative tumor suppressor gene tissue inhibitor of metalloproteinase-3...

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PMID: 12629131
DOI: 10.1210/jc.2002-021027

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