Article
Promoter methylation and expression of TIMP3 gene in gastric cancer.
Diagnostic pathology - 2 Jul 2013
Guan ZhiYu, Zhang Jun, Song ShiHui, Dai DongQiu
Abstract excerpt
BACKGROUND: Gastric carcinoma development is a multi-stage process that involves more than one gene. Aberrant changes in DNA methylation are considered as the third mechanism that leads to anti-oncogene inactivation, which plays an essential role in tumor development. In this study, we assessed the relationship among the aberrant methylation of the promoter CpG islands of tissue inhibitor of metalloproteinase 3...
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