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Article

Mutation analysis of the Smad3 gene in human ovarian cancers.

International journal of oncology - 1 Nov 1999

Wang D, Kanuma T, Takama F, Mizumuma H, Ibuki Y, Wake N, Mogi A, Shitara Y, Hagiwara K, Takenoshita S

Abstract excerpt

The Smad3 gene is a member of the Smad family, vertebrate homologues of Drosophila Mad, and its gene product is a cytoplasmic element in the transforming growth factor-beta (TGF-beta) signaling pathway. Mutations in TGF-beta receptors and their cytoplasmic elements of transduction signals commonly accompany various cancers. Using PCR-SSCP analysis we searched for the presence of Smad3 gene mutations in 36 human...

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PMID: 10536178
DOI: 10.3892/ijo.15.5.949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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