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Article

Significant role of genetics in IBD: the NOD2 gene.

Reviews in gastroenterological disorders - 1 Jan 2003

Cho Judy H

Abstract excerpt

Inflammatory bowel disease (IBD) clusters within families, suggesting a genetic component to disease pathogenesis. Studies have identified a gene on chromosome 16cen that confers susceptibility to Crohn's disease. The affected gene codes for the NOD2/CARD15 protein, which is involved in the immune system's response to bacterial infection. Multiple mutations have been identified, three of which have been shown to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Intracellular Signaling Peptides and Proteins

Share to Nod2 Signaling Adaptor Protein

Source

Identifiers

PMID: 12684585

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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