Article
Advances and perspectives in the genetics of inflammatory bowel diseases.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Feb 2006
Chamaillard Mathias, Iacob Razvan, Desreumaux Pierre, Colombel Jean-Frederic
Abstract excerpt
Several clinical and biological phenotypes define complex diseases such as inflammatory bowel disease (IBD). There is a critical role of the caspase recruitment domain protein 15/nucleotide-binding oligomerization protein 2-dependent (CARD15-NOD2) sensing of bacterial cell wall components in health and disease. The current etiologic model for IBD emphasizes an interaction between susceptibility and modifier genes...
Topics
- Crohn Disease
- Genetic Predisposition to Disease
- Humans
- Inflammatory Bowel Diseases
- Intracellular Signaling Peptides and Proteins
- Nod2 Signaling Adaptor Protein