Article
The role of genetics in inflammatory bowel disease.
Current drug targets - 1 May 2008
Henckaerts Liesbet, Figueroa Carolina, Vermeire Séverine, Sans Miquel
Abstract excerpt
The volume of research undertaken on the genetic susceptibility of inflammatory bowel disease (IBD) has been tremendous. Genome-wide linkage studies pointed towards more than 10 chromosomal regions and fine-mapping of these regions led to the identification of a number of genes, including CARD15 (NOD2), DLG5, OCTN1 and 2, TLR4 and CARD4 (NOD1). With the recent completion of the human genome project, whole genome...
Topics
- ATP Binding Cassette Transporter, Subfamily B
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Genetic Linkage
- Genetic Predisposition to Disease
- Genotype
- HLA Antigens
- Humans
- Inflammatory Bowel Diseases
- Membrane Proteins
- Nod1 Signaling Adaptor Protein