Article
The role of genetics in inflammatory bowel disease.
Current drug targets - 1 May 2008
Henckaerts Liesbet, Figueroa Carolina, Vermeire Séverine, Sans Miquel
Abstract excerpt
The volume of research undertaken on the genetic susceptibility of inflammatory bowel disease (IBD) has been tremendous. Genome-wide linkage studies pointed towards more than 10 chromosomal regions and fine-mapping of these regions led to the identification of a number of genes, including CARD15 (NOD2), DLG5, OCTN1 and 2, TLR4 and CARD4 (NOD1). With the recent completion of the human genome project, whole genome...
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