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CGHScan: finding variable regions using high-density microarray comparative genomic hybridization data.

BMC genomics - 25 Apr 2006

Anderson Bradley D, Gilson Michael C, Scott Abigail A, Biehl Bryan S, Glasner Jeremy D, Rajashekara Gireesh, Splitter Gary A, Perna Nicole T

Abstract excerpt

BACKGROUND: Comparative genomic hybridization can rapidly identify chromosomal regions that vary between organisms and tissues. This technique has been applied to detecting differences between normal and cancerous tissues in eukaryotes as well as genomic variability in microbial strains and species. The density of oligonucleotide probes available on current microarray platforms is particularly well-suited for...

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PMID: 16638145
DOI: 10.1186/1471-2164-7-91
PMCID: PMC1464128

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