Article
Detection of genome-wide polymorphisms in the AT-rich Plasmodium falciparum genome using a high-density microarray.
BMC genomics - 25 Aug 2008
Jiang Hongying, Yi Ming, Mu Jianbing, Zhang Louie, Ivens Al, Klimczak Leszek J, Huyen Yentram, Stephens Robert M, Su Xin-Zhuan
Abstract excerpt
BACKGROUND: Genetic mapping is a powerful method to identify mutations that cause drug resistance and other phenotypic changes in the human malaria parasite Plasmodium falciparum. For efficient mapping of a target gene, it is often necessary to genotype a large number of polymorphic markers. Currently, a community effort is underway to collect single nucleotide polymorphisms (SNP) from the parasite genome. Here...
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