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Article

Optimal probe length varies for targets with high sequence variation: implications for probe library design for resequencing highly variable genes.

PloS one - 18 Jun 2008

Haslam Niall J, Whiteford Nava E, Weber Gerald, Prügel-Bennett Adam, Essex Jonathan W, Neylon Cameron

Abstract excerpt

BACKGROUND: Sequencing by hybridisation is an effective method for obtaining large amounts of DNA sequence information at low cost. The efficiency of SBH depends on the design of the probe library to provide the maximum information for minimum cost. Long probes provide a higher probability of non...

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PMID: 18563203
DOI: 10.1371/journal.pone.0002500
PMCID: PMC2430613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18563203-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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