Article
Mutations in the Parkinson's disease genes, Leucine Rich Repeat Kinase 2 (LRRK2) and Glucocerebrosidase (GBA), are not associated with essential tremor.
Parkinsonism & related disorders - 1 Feb 2010
Clark Lorraine N, Kisselev Sergey, Park Naeun, Ross Barbara, Verbitsky Miguel, Rios Eileen, Alcalay Roy N, Lee Joseph H, Louis Elan D
Abstract excerpt
We evaluated an association between essential tremor (ET) and the Parkinson's disease (PD) genes, Leucine Rich Repeat Kinase 2 (LRRK2) and Glucocerebrosidase (GBA). Clinical studies demonstrate an association between ET and PD, suggesting possible shared pathophysiologies, yet LRRK2 has rarely been studied in ET, and GBA, not at all. ET cases (n = 275, including 42 with rest tremor) and controls (n = 289) were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.