Penetrance estimate of LRRK2 p.G2019S mutation in individuals of non-Ashkenazi Jewish ancestry.

doi:10.1002/mds.27059

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Article

Penetrance estimate of LRRK2 p.G2019S mutation in individuals of non-Ashkenazi Jewish ancestry.

Movement disorders : official journal of the Movement Disorder Society - 1 Oct 2017

Lee Annie J, Wang Yuanjia, Alcalay Roy N, Mejia-Santana Helen, Saunders-Pullman Rachel, Bressman Susan, Corvol Jean-Christophe, Brice Alexis, Lesage Suzanne, Mangone Graziella, Tolosa Eduardo, Pont-Sunyer Claustre, Vilas Dolores, Schüle Birgitt, Kausar Farah, Foroud Tatiana, Berg Daniela, Brockmann Kathrin, Goldwurm Stefano, Siri Chiara, Asselta Rosanna, Ruiz-Martinez Javier, Mondragón Elisabet, Marras Connie, Ghate Taneera, Giladi Nir, Mirelman Anat, Marder Karen

Abstract excerpt

BACKGROUND: Penetrance estimates of the leucine-rich repeat kinase 2 (LRRK2) p.G2019S mutation for PD vary widely (24%-100%). The p.G2019S penetrance in individuals of Ashkenazi Jewish ancestry has been estimated as 25%, adjusted for multiple covariates. It is unknown whether penetrance varies among different ethnic groups. The objective of this study was to estimate the penetrance of p.G2019S in individuals of...

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PMID: 28639421
DOI: 10.1002/mds.27059
PMCID: PMC5656509

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Source receipt: pubmed, retrieved 6 Sept 2026.

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