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Article

The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes.

Journal of cell science - 1 May 2015

Khatter Divya, Raina Vivek B, Dwivedi Devashish, Sindhwani Aastha, Bahl Surbhi, Sharma Mahak

Abstract excerpt

The homotypic fusion and protein sorting (HOPS) complex is a multi-subunit complex conserved from yeast to mammals that regulates late endosome and lysosome fusion. However, little is known about how the HOPS complex is recruited to lysosomes in mammalian cells. Here, we report that the small GTPase Arl8b, but not Rab7 (also known as RAB7A), is essential for membrane localization of the human (h)Vps41 subunit of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25908847
DOI: 10.1242/jcs.162651
PMCID: PMC4432227

Genes

EGFR
PLEKHM2

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