Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A role for p300/CREB binding protein genes in promoting cancer progression in colon cancer cell lines with microsatellite instability

19 Jan 2004

Abstract excerpt

Our manipulation of the nonsense-mediated decay pathway in microsatellite unstable colon cancer cell lines identified the p300 gene as a potential tumor suppressor in this subtype of cancer. Here, we have demonstrated that not only the p300 gene but also the highly homologous cAMP-response element-binding protein (CREB) binding protein (CBP) gene together are mutated in >85% of microsatellite instability (MSI)+...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Cancer-related Molecular Pathways
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14732695
DOI: 10.1073/pnas.0307276101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

A role for p300/CREB binding protein genes in promoting cancer progression in colon cancer cell lines with microsatellite instabilityPMID 14732695Read ↗

Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.Semantic proximity Read ↗

Dysregulation of the p300/CBP histone acetyltransferases in human cancer.Semantic proximity Read ↗

Nonsense mediated decay resistant mutations are a source of expressed mutant proteins in colon cancer cell lines with microsatellite instability.Semantic proximity Read ↗

Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression.Semantic proximity Read ↗

p300/CBP and cancerSemantic proximity Read ↗

[Effect of mutation in the p300 transcription coactivator on transcriptional response and cell proliferation of human carcinoma cell lines].Semantic proximity Read ↗

Growth suppression of human carcinoma cells by reintroduction of the p300 coactivator.Semantic proximity Read ↗

Mutations truncating the EP300 acetylase in human cancers.Semantic proximity Read ↗

Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations.Semantic proximity Read ↗

Absence of p300 induces cellular phenotypic changes characteristic of epithelial to mesenchyme transition.Semantic proximity Read ↗

Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.