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Article

Triggering of T cell activation via CD4 dimers.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2006

Moldovan Maria-Cristina, Sabbagh Laurent, Breton Gaëlle, Sékaly Rafick-Pierre, Krummel Matthew F

Abstract excerpt

The onset of activation in Th cells is triggered by localized co-engagement of TCRs and the coreceptor CD4. A CD4 crystal suggested that CD4 may form dimers in some circumstances. In this study, we use live-cell fluorescence resonance energy transfer imaging to demonstrate that CD4 dimers are present at a basal level on the cell surface and accumulate at the synapse. Mechanistically, we reveal two conditions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16622011
DOI: 10.4049/jimmunol.176.9.5438

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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