Article
CD4 dimerization requires two cysteines in the cytoplasmic domain of the molecule and occurs in microdomains distinct from lipid rafts.
Molecular immunology - 1 Oct 2010
Fournier Margot, Peyrou Marion, Bourgoin Lucie, Maeder Christine, Tchou Isabelle, Foti Michelangelo
Abstract excerpt
CD4 is engaged in APC-mediated T-cell activation and serves as the primary receptor for HIV. CD4 dimerization and location in specific microdomains has been previously suggested to control its pathophysiological activity. In this study, we investigated (i) whether the CD4 cytoplasmic domain contributes to its dimerization by evaluating the dimerization of mutants, bearing deletions or point mutations in their...
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